Advisory Board

Dr. Kwadwo Asamoah Kusi, B.Sc., M.Phil.(Ghana), Ph.D. (Leiden)
Email : akusi@noguchi.ug.edu.gh
Phone : +233-302-501178
Fax : +233-302-502182
Department : Immunology
 
 
Biography
Dr. Kwadwo A.Kusijoined the Immunology Department of NMIMR in 2003 as an M.Phil. research student. In 2007 heundertook PhD studies(Vaccine Immunology)at Leiden University Medical Centre (LUMC),Netherlands andreturned in February 2012 as one of the first two Fellows under NMIMR’s Postdoctoral training programme.Dr. Kusialso has B.Sc. (2000) and M.Phil. (2005) degrees both in Biochemistry, from the University of Ghana, Legon. He is married to Stella, a graduate teacher with Adonten Senior High School at Aburi and they have two wonderful children; four year old Cheryl and two year old Sean.
 
Research Interest

1. Humoral and cellular immunology of infectious diseases.
2. Identification of and evaluation of biomarkers of disease progression/transmission.
3. Identification and evaluation of antibody and T cell correlates of immunity to malaria.
4. Development of immunoassays for the evaluation of infectious disease biomarkers.

 
Projects
  1. Title: Association of strong T cell responses to HLA class I-restricted CSP and AMA1 epitopes with the risk of P.
    falciparum infection. UGRF
    Role: Principal Investigator.

  2. Title: Relationship between antibody recognition by P. falciparum pre-erythrocytic vaccine candidate antigens and clinical and parasitological ;protection against malaria in an antigen endemic area.
    Role: Co-Investigator
    US Congressional Funds

  3. Title: Immortalization of B cells from P. falciparum-exposed individuals for the production of parasite-specific monoclonal antibodies. TWAS
    Role:  Principal Investigator.


  4. Functional immunogenetic correlates of immunity to malaria.
    Role: Co-Investigator
    DANIDA Funds.

 

Peer-reviewed publications

Kusi K.A., Bosomprah S, Dodoo D, Kyei-Baafour E, Dickson E.K., Mensah D.A., Angov E, Dutta S, Sedegah M and Koram K.A. (2014). Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation.Malaria Journal 13:103.

Adukpo S, Kusi K.A., Ofori M , Tetteh J.K.A., Amoako-Sakyi D,
Goka B.Q., Adjei G.O., Edoh D.A., Akanmori B.D., Gyan B.A., and Dodoo D. (2013).High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria. PLoSONE 8(12): e84181. doi:10.1371/journal.pone.0084181.

Kusi K.A., Dodoo D, Bosomprah S, van der Eijk M, Faber B.W., Kocken C.H.M. and Remarque E.J. (2012). Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population.BMC Infectious Diseases, 12:32

Kusi K.A., Remarque E.J., Riasat V, Walraven V, Thomas A.W., Faber B.W. and Kocken C.H.M. (2011). Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques.Malaria Journal, 10:182

Kusi K.A., Faber B.W., van der Eijk M, Thomas A.W., Kocken C.H.M. and Remarque E.J. (2011). Immunisation with different PfAMA1 alleles in sequenceinduces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits.Malaria Journal, 10:40

Kusi K.A., Faber B.W., Riasat V, Thomas A.W., Kocken C.H.M. and Remarque E.J. (2010). Generation of humoral immune responses to multi-allele PfAMA1 allele vaccines; effect of adjuvant and the number of component alleles on the breadth of response.PLoS ONE5(11): e15391. doi:10.1371/journal.pone.0015391

Kusi K.A., Faber B.W., Thomas A.W. and Remarque E.J. (2009). Humoral immune response to mixed PfAMA1 alleles; Multivalent PfAMA1 vaccines induce broad specificity. PLoS ONE4(12): e8110. doi:10.1371/ journal.pone.0008110

Courtin D, Oesterholt M, Huismans H, Kusi K, Milet J, Badaut C, Gaye O, Roeffen W, Remarque E.J., Sauerwein R, Garcia A and Luty A.J.F. (2009). The quantity and quality of African Children’s IgG responses to Merozoite Surface Antigens reflect protection against Plasmodium falciparum Malaria. PLoS ONE4(10): e7590. doi:10.1371/journal.pone.0007590

Gyan B, Goka B.Q., Adjei G.O., Tetteh J.K., Kusi K.A., Aikins A, Dodoo D, Lesser M.L., Sison C.P., Das S, Howard M.E., Milbank E, Fischer K, Rafii S, Jin D and Golightly L.M. (2009). Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children.Am J Trop Med Hyg.80(4): 541-6.

Dodoo D, Aikins A, Kusi K.A., Lamptey H, Remarque E, Milligan P, Bosomprah S, Chilengi R, Osei Y.D., Akanmori B.D. and Theisen M (2008). Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children.Malar J7: 142. doi:10.1186/1475-2875-7-142

Kusi K.A., Gyan B.A., Goka B.Q., Dodoo D, Adjei G.O., Troye-Blomberg M, Akanmori B.D. and Adjimani J.P. (2008). Levels of Soluble CD163 and Severity of Malaria in Children in Ghana.Clinvacc. Immunol. 15: 1456-60. Epub 2008 Jul 16.

 
Books
Towards a blood stage malaria vaccine; dealing with allelic polymorphism in the vaccine candidate apical membrane antigen 1”, PhD thesis (2012).
 
 
Dr. Kwadwo Asamoah Kusi
DR. Evelyn Yayra Afua Bonney Kingsley Badu
     
Dr Aminata Colle LO Samuel Asamoah Sakyi Dr. Jewelna Akorli
(nee Osei-Poku)
     
Dr Patrick Valere Tsouh Fokou
Dr. Patrick Kobina Arthur Dr. Joseph Mwanzia Nguta
     
 
Dr Edward Maina Protus Arrey Tarkang