Advisory Board

Kingsley Badu
Email : kbadu@noguchi.ug.edu.gh
Phone :(+233)265012563
Fax :
Department : Immunology
 
 
Biography

Kingsley Badu has a B.Sc (Hons), in Biological Sciences, an M.Phil in Clinical Microbiology, and a PhD in Theoretical and Applied Biology from the Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana. He also has a certificate in Cell Biology of infectious Pathogens from the American Society of Cell Biology (ASCB), and advance training in ‘Biomarkers of exposure, susceptibility and disease’ at the Imperial College, London UK.

Kingsley has extensive professional experience working with local and international research institutions. Notably, he worked with the Kumasi Centre of Collaborative Research for Tropical Medicine, from 2002-2006 where he investigated and contributed to the literature on the transmission dynamics of Malaria, Onchocerciasis and Lymphatic Filariasis. As a Ph.D student, he worked as a visiting scientist with the Center for Global Health Research, Kenya Medical Research Institute (KEMRI) from 2008-2012. Here he investigated the heterogeneities in human exposure to malaria parasites and vectors in the highlands. Still in Kenya he worked with the Laboratory of Viral and Parasitic Diseases, University of New Mexico/KEMRI, and the Basic Science Laboratory of the United States Army Medical Research Unit Kenya (USARMU-K), He studied molecular epidemiology and immuno-epidemiology of malaria in the western Kenyan Highlands at the respective institutions. He also worked with the Prof. Yan Laboratories in the College of Health Science, University of California at Irvine, USA: where he obtained advanced training in molecular biology.  Interestingly between the period of 2006 and 2008 when he was not actively engaged in research he served as a quality assurance officer (Microbiology) at the then Kumasi breweries limited and then thought Clinical Microbiology in the school of Nursing at the Garden City University College.

 
Project Name

Developing innovative tools for the measurement of malaria transmission intensity and surveillance

 
Research Interest

The Theme of : Heterogeneity in the risk of malaria exposure is present at all levels of endemicity; becoming very significant at the community levels. In malaria, the so called ‘Hotspots’ of higher malaria transmission are likely to hamper malaria elimination efforts because undetected residual foci of persistent malaria infection seed transmission to the wider community.
As a result, assessment of exposure to malaria vectors is relevant to understanding spatial and temporal variations malaria transmission and facilitates targeting of control strategies.  Vector exposure is typically assessed as a component of the EIR; However, a direct assessment of EIR to determine small-scale variation in malaria exposure is operationally unattractive. 
Serological tools based on human antibody responses to PfMSP119, PfCSP and Anopheles gambiae salivary gland protein (gSG6) have recently shown promise in estimating malaria transmission intensity. However, because intense mosquito exposure may not necessarily mean a high malaria exposure if anopheline are not infected and mosquito sporozoite rates may also show spatial variation, is critical to obtain additional mosquito-staged sporozoite proteins biomarkers that will indicate exposure to sporozoite infected bites.

My current research focus is looking at gene transcript and expression profiles of Ookinete and sporozoite staged invasion proteins (the so called glideosome) of Plasmodium falciparum to elucidate their functional interactions in the invasion process. The goal is to identify candidate genes/proteins biomarkers capable of assessing the human-parasite-vector interactions. It is Hypothesized that peptides based on Plasmodium falciparum sporozoite and ookinete proteins expressed during the mosquito stages such as (Secreted ookinete protein, putative - PSOP-24, Circumsporozoite-related antigen - CRA, Conserved P. falciparum protein expressed in salivary glands (PFE_0565w which is currently renamed as PF3D7_0511_400 has the potential to be the ideal biomarker that will represent the Man-parasite-vector interactions.

 
Articles in Peer-Reviewed Biomedical Journals

Badu K, Siangla J, Larbi J, Lawson BW, Afrane Y, Ong'echa M, Remoue F, Zhou G, Githeko AK and Yan G (2012): Variation in exposure to Anopheles gambiae salivary gland peptide (gSG6-P1) across different malaria transmission settings in the western Kenya Highlands Malaria Journal. 2012, 11:318  

Badu K, Afrane YA, Larbi J, Stewart VN, Waitumbi J, Angov E, Ong’echa JM, Perkins  DJ, Zhou G,  Githeko A, and Yan G: Marked variation in MSP-119 antibody responses to malaria in western Kenyan Highlands. BMC Infectious Diseases 2012, 12:50

Mills-Robertson FC, Tay SCK, Duker-Eshun G, Walana W, and Badu K (2012): In vitro antimicrobial activity of ethanolic fractions of Cryptolepis sanguinolenta Ann Clin Microbiol Antimicrob. 2012; 11: 16. 

Tay SCK, Danuor SK, Mensah DC, Acheampong G, Abruquah HH, Morse A, Caminade C, Badu K, Tompkins A. and Hassan HA: Climate Variability and Malaria Incidence in Peri-Urban, Urban and Rural Communities around Kumasi, Ghana: A Case Study at three Health Facilities; Emena, Atonsu and Akropong.  International Journal of Parasitology Research 2012, 4(2): 83-89

Tay, SCK, Danuor SK, Morse A, Caminade C, Badu K, and Hoffman HA: Entomological Survey of Malaria Vectors within the Kumasi Metropolitan Area—A Study of Three Communities: Emena, Atonsu and Akropong." Journal of Environmental Science and Engineering 1, no. 2 (2012): 144-154.

Tuno N, Kjaerandsen J, Badu K, Kruppa T (2010) Blood-Feeding Behaviour of Anopheles gambiae and Anopheles melas in Ghana, Western Africa. Journal of Medical Entomology 2010 Vol. 47, Issue 1, pg(s) 28-31

Badu K, Afrane Y, Larbi J, Stewart A, Waitumbi J, Zhou G, and Yan, G. (2010). Spatial and Temporal Pattern of Anti-malaria Antibody Responses as Evaluation of Human Exposure in the Western Kenyan Highlands. American Journal of Tropical Medicine and Hygiene (Vol. 83 No. 5, pp. 81-81).

 
 
Dr. Kwadwo Asamoah Kusi
DR. Evelyn Yayra Afua Bonney Kingsley Badu
     
Dr Aminata Colle LO Samuel Asamoah Sakyi Dr. Jewelna Akorli
(nee Osei-Poku)
     
Dr Patrick Valere Tsouh Fokou
Dr. Patrick Kobina Arthur Dr. Joseph Mwanzia Nguta
     
 
Dr Edward Maina Protus Arrey Tarkang